Detailed Abstract
[E-poster]
[E50] The Prognostic Values Of The Lymph Node Ratio In Patients With Distal Cholangiocarcinoma After Curative Intended Surgery: A Single Center Retrospective Study
Hee Joon KIM*1 , Chol Kyoon CHO1 , Yang Seok KOH1 , Young Hoe HUR1 , Eun Kyu PARK1 , Sang Hwa SONG1
1 Department Of Surgery, Chonnam National University Medical School, REPUBLIC OF KOREA
Background : The goal of the study was to evaluate the prognostic value of lymph node ratio (LNR) in distal cholangiocarcinoma (DCC).
Methods : Clinicopathologic data of 162 patients who underwent radical intended surgery for DCC between 2012 and 2020 were analyzed retrospectively. Prognostic factors related to overall survival (OS) and disease-free survival (DFS) were evaluated.
Results : Median OS time and DFS time was 41 and 29 months, and 5-year OS rate and DFS rate was 44.4% and 21.1%, respectively. In univariate analysis, significant prognostic factors for OS were histologic differentiation, AJCC stage, positive lymph node count, LNR, R1 resection, and perineural invasion. Preoperative CEA, CA19-9, infiltrative type, histologic differentiation, AJCC stage, positive lymph node count, LNR, R1 resection, perineural invasion, and lymph-vascular invasion were significant in univariate analysis for disease-free survival. In multivariate analysis, histologic differentiation, R1 resection, and LNR were the independent prognostic factors for both OS and DFS. LNR ≥ 0.2 group significantly had a poor prognosis in terms of OS (HR 3.915, p = 0.002) and DFS (HR 5.840, p < 0.001).
Conclusions : LNR has significant value as a prognostic factor of DCC related with overall survival and disease free survival. LNR has potential to be used as modified staging system with furthermore studies.
Methods : Clinicopathologic data of 162 patients who underwent radical intended surgery for DCC between 2012 and 2020 were analyzed retrospectively. Prognostic factors related to overall survival (OS) and disease-free survival (DFS) were evaluated.
Results : Median OS time and DFS time was 41 and 29 months, and 5-year OS rate and DFS rate was 44.4% and 21.1%, respectively. In univariate analysis, significant prognostic factors for OS were histologic differentiation, AJCC stage, positive lymph node count, LNR, R1 resection, and perineural invasion. Preoperative CEA, CA19-9, infiltrative type, histologic differentiation, AJCC stage, positive lymph node count, LNR, R1 resection, perineural invasion, and lymph-vascular invasion were significant in univariate analysis for disease-free survival. In multivariate analysis, histologic differentiation, R1 resection, and LNR were the independent prognostic factors for both OS and DFS. LNR ≥ 0.2 group significantly had a poor prognosis in terms of OS (HR 3.915, p = 0.002) and DFS (HR 5.840, p < 0.001).
Conclusions : LNR has significant value as a prognostic factor of DCC related with overall survival and disease free survival. LNR has potential to be used as modified staging system with furthermore studies.
SESSION
E-poster
E-Session 12/03 ALL DAY